Vitamin E is a potential agent for preventing or treating osteoarthritis because of its antioxidant and anti-inflammatory effects. A number of vitamins have been studied to determine their effects on arthritis, including antioxidant vitamins A, C and E, and vitamins D and K. So far, there is no evidence that taking antioxidant vitamins improves arthritis symptoms, although eating a diet rich in these nutrients is generally healthy. Vitamins D and K are important for bone strength, and vitamin K is involved in the structure of cartilage.
Supplementing these two nutrients can be helpful if you're deficient in them. We included men and women aged 40 years or older who met the American Rheumatism Association14 clinical diagnostic criteria for knee arthrosis and who had radiographic evidence of osteophytes or joint space narrowing. Effect of gamma-tocotrienol in the fight against oxidative stress and joint damage in collagen-induced arthritis in rats. Currently, this is mainly supported by observational data, such as the Framingham study, which has suggested a reduction in the prevalence, but not the incidence, of knee arthrosis in people with a high dietary intake of vitamin E.
The signs of joint pain included joint swelling and redness, limited mobility and pain to the touch. The improvement of both clinical scores in this research is possibly related to the analgesic effect of vitamin E itself, the increase in antioxidants and the decrease in the oxidative level. Cell studies showed that vitamin E mitigated oxidative stress in cartilage explants or in chondrocyte culture caused by mechanical stress or free radicals. It should be noted that treatment with TRF reduced the levels of IL-1β and IL-6 proteins, in line with the reduction of joint swelling.
At six months, the deterioration of the pain score was lower in the placebo group than in the vitamin E group, after adjusting for age, gender, BMI, radiological score and the use of analgesics and anti-inflammatory drugs. Recently, there has been increasing evidence that vitamin E, a fat-soluble vitamin and one of the main dietary antioxidants, may play a role in osteoarthritis. Refined, bleached and deodorized vitamin E oil (RBD) was obtained from the Engineering Department of the Malaysian Palm Oil Board (Selangor, Malaysia). Learn what supplements and vitamins can help with arthritis symptoms and what risks some may pose.
Status of lipid peroxidation, glutathione, ascorbic acid, vitamin E and antioxidant enzymes in patients with arthrosis. Regarding total antioxidant and antioxidant capacity, the levels of vitamin E (alpha-tocopherol), FRAP and TEAC in group B were higher than those in group A in both plasma and synovial fluid. Oxidative stress is one of the many proposed mechanisms that underpin joint degeneration in osteoarthritis.
